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According to the UK Summary of Product Characteristics (SmPC), the 300 mg dose should only be used in patients with an eGFR of 60 mL/min/1.73m or above

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A credible functional line for todays customer looks like: an unsweetened or lightly sweetened protein option, an electrolyte or hydration drink, and a low-sugar prebiotic or sparkling option in smaller serve sizes than the old default

Park, S.-Y., Camilleri, M., Packer, D

This method allows for faster absorption and can be particularly helpful for those who may not absorb nutrients well from food alone