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Qi et al., 2024), which is especially intriguing given that hypothalamus is assumed to be responsible for CTS synthesis in the brain

Fingolimod, a S1P receptor modulator and agonist, improves the relapse rate in RRMS, with controversial effects in the SPMS and no effect in PPMS (119121)

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They tend to have less consistent evidence and are generally less effective, particularly for moderate to severe menopause symptoms