Now their stomachs are paralyzed July 25, 2023 Facial lipoatrophy with semaglutide-related weight loss February 10, 2023 --------------------------------------- Glucagon-like peptide 1 (GLP-1) agonists are medications approved for treatment of diabetes that recently have also been used off label for weight loss.1 Studies have found increased risks of gastrointestinal adverse events (biliary disease,2 pancreatitis,3 bowel obstruction,4 and gastroparesis5) in patients with diabetes.2-5 Because such patients have higher baseline risk for gastrointestinal adverse events, risk in patients taking these drugs for other indications may differ
If prescribed Ozempic off-label elsewhere, discussing the transition to a medication with a weight loss indication could even improve insurance approval rates
Stacking is unsafe and not evidence-based
Obesity is also associated with increased inflammation and is a major risk factor for insulin resistance.Insulin resistance can also be caused by genetic factors, including mutations in genes involved in insulin signaling pathways
Glucagon Receptor Investigations Glucagon signaling plays a central role in energy mobilization and metabolic balance
JAMA 327 , 17041706 (2022)