ROS-activation of Apoptosis Signal-regulating Kinase/c-Jun N-terminal kinase/p38 (ASK1-JNK/p38) and Mitogen-Activated Protein Kinase (MAPK), results in cell death
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The functional intracellular status of micronutrients involved in cell metabolism is evaluated by manipulation of the individual micronutrients in the media, followed by mitogenic stimulation and measurement of DNA synthesis