When used topically or systemically, it can lighten hyperpigmented spots and even out skin tone
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10.1038/s41598-023-50781-2 168 HaoW.WuJ.YuanN.GongL.HuangJ.MaQ.et al
Importantly, they also measured physical performance too (7)
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At 40 weeks, all three doses (3 mg, 12 mg, 36 mg) of orforglipron achieved the primary endpoint of superior A1C reduction compared to placebo , lowering A1C by 1.3% to 1.6% from a baseline of 8.0% , with improvements seen as early as 4 weeks