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It acts through the GPCR receptors VPAC1 and VPAC2, activating cAMP-related signaling pathways that regulate vascular tone, immune balance, secretion mechanisms, and neuronal survival

In a murine lupus model, oral Lactobacillus acidophilus restored cecal microbiota composition in lupus-prone mice and regulated the Th17/Treg cell balance by decreasing Th17 cells and increasing Treg cell proportions, while enhancing the efficacy of the immunosuppressant tacrolimus [87]

Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat

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