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S., Kwon, E

NICE guidance (NG28) recommends GLP-1 therapy for type 2 diabetes when metformin and other oral medications haven't achieved adequate control, typically in combination with insulin or as an alternative to insulin in specific circumstances

It targets the liver and adipose tissue to increase energy expenditure (thermogenesis) and promote the breakdown of stored fats

Abbreviations AA: Amino acid [Ca 2+ ] i : Cytoplasmic free Ca 2+ concentration DPP-4: Dipeptidyl peptidase 4 EGFP: Enhanced green fluorescent protein GCGR: Glucagon receptor GLP-1: Glucagon-like peptide 1 GLP-1R: GLP-1 receptor GPCR: G protein-coupled receptor GRA: Glucagon receptor antagonist IC 50 : Half-maximal inhibitory concentration NPY: Neuropeptide Y PKA: Protein kinase A PPPG: Preproglucagon promoter P/Q-type Ca 2+ channel: Voltage-gated Ca 2+ channel sensitive to -agatoxin PTX: Pertussis toxin TIRF (microscopy): Total internal reflection fluorescence (microscopy) VGCC: Voltage-gated calcium channel References Cryer PE (2015) Hypoglycemia-associated autonomic failure in diabetes: maladaptive, adaptive, or both

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Indicated in the physical preparation of high performance horses, subjected to stress, growing, convalescent or with chronic fatigue