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The detailed mechanism is that the non-structural protein NS1 of ZIKV recruits the host deubiquitinase USP8 to cleave K11-linked poly-ubiquitin chains from caspase-1 at Lys134 to inhibit the proteasomal degradation of caspase-1
To mitigate this, we applied strict inclusion criteria, requiring complete medical records for all eligible patients
Acknowledgements The authors would like to thank every researcher that contributed to the understanding of the close relationship between the IGF-1 deficiency and the Metabolic Syndrome establishment
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