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These medications work through different but related mechanismssemaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, while tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

Because many peptides are not FDA-approved, our Baltimore medical team reviews your history, individualizes dosing, and monitors your progress to manage potential risks

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2016;8:364ra152

If neurological symptoms worsen or fail to improve after four to six weeks of appropriate treatment , further investigation is necessary to exclude alternative diagnoses or complications

We typically recommend a 24 week break after 812 weeks on for chronic protocols the necessity isn't fully established, but it's a sensible conservative approach for long-term use