By activating GIP receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia
Diabetes Ther 15 , 547563 (2024)
Moreover, ErbB2 can form heterodimers with IGF-IR in IGF-IR inhibitor-resistant cancer cells, leading to the induction of ErbB2 phosphorylation by IGF2 [177]
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