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Conventional DMARDs (e.g., methotrexate, leflunomide, sulfasalazine): Methotrexate slows joint damage and suppresses inflammation but causes hepatic toxicity and bone marrow suppression, leading to 30% treatment discontinuation within one year (8)

In conclusion, this is the first study to show that NRTP can impair ovarian function through multiple pathways (fibrosis, PMF overactivation, and inflammation)

Her typical approach is to focus on removing the offending autoimmune triggers, but she is also a proponent of using Low Dose Naltrexone (LDN) in this instance as well

Although heterozygous mice were viable and fertile, they only had a 20% reduction in GSH levels making it an unideal model to study glutathione metabolism (51)

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Turns out, they were onto something