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Atherosclerosis is a pathological state that is distinguished by a deviation from the typical physiological behavior of endothelial cells

J., Lu, L

Increased apoD and apoA-IV help counteract the chemical modification of high-density lipoprotein (HDL) by advanced glycation end products (AGEs) and carbamylation, which contributes to the loss of function of HDL in maturing DKD, thereby delaying DKD (192)

doi: 10.1016/j.ajcnut.2024.01.007

Ulland, Eyal David, et al

In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more