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BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations

Clinical impact

current research is also exploring novel GLP-1 RA combinations [23, 24]

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That short window is actually the point it produces discrete, pulsatile GH release that more closely mirrors natural secretion patterns

How it supports weight loss: By slowing the rate at which food leaves your stomach and stabilizing blood sugar, semaglutide helps control hunger and makes it easier to maintain balanced eating habits