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For semaglutide-related constipation, longer-term use may be appropriate under clinician guidance

Drug makers are currently working on targets such as amylin, which preserves lean muscle while aiding fat loss

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This supports a shift from fat storage toward fat burning

This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature

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