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For topical formulations, concentrations of 0.1 to 0.3 percent are used, with efficacy detectable from as low as 0.01 percent

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However, each of the four products can be oxidized to 3-ketosteroids with a concomitant double bond isomerization to give progesterone, 17-hydroxyprogesterone, androstenedione, and testosterone, respectively (Figure 7), and the alternative route to the sex hormones is named the delta4-pathway