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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Mechanism #4: Reduced Food Intake = Less Diet-Induced Thermogenesis Whats happening: Food is fuel, and digesting it generates heat

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Our results delineate that TMPRSS2-PAR2 signaling regulates postprandial GIP release in lean mice, but that this signaling axis is overlaid by additional functions of TMPRSS2 in the context of hypercaloric weight gain and the associated dysregulation of glucose homeostasis and insulin resistance