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Specifically, issues with the Randomization process (D1) were noted in three studies (17, 42, 43) and concerns regarding Deviations from the intended interventions (D2) were observed in two study (17, 43)

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Yildirim-Balatan C, Fenyi A, Besnault P, Gomez L, Sepulveda-Diaz JE, Michel PP, et al

3), which is known to upregulate the expression of genes involved in amino acid transport or synthesis, one-carbon metabolism, and glutathione biosynthesis 33,34 (Fig