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Chakhtoura M, Haber R, Ghezzawi M et al (2023) Pharmacotherapy of obesity: an update on the available medications and drugs under investigation

Treatment starts with a lower dose of tirzepatide, gradually increasing to reach weight loss and health goals

May occur with histiocytic sarcoma in rats or mice

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Furthermore, the downregulation of proinflammatory cytokines, upregulation of the antioxidant SOD, and significant reductions in the expression of the iNOS and COX-2 proteins after activation of the NF-B and Nrf2 pathways were also observed in rats, confirming the effective therapeutic effects of perillyl alcohol [154] (Table 2)