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In cardiomyocytes, a reduction in CCO activity compromises mitochondrial energy production [243]

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It has low water solubility (0.6-1.2 mg/litre at 25C) and an octanol/water partition coefficient (log K ow ) of 2.882

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In addition, SLC7A11, the antiporter providing intracellular cystine (necessary to maintain intracellular GSH levels) also increased (Figure 2C and Supplemental Figure 2A)