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Moderately and severely affected individuals have enzymes with dysfunctional catalytic sites, rendering it unable to participate in detoxification reactions

Listening to music at the maximum setting on many personal listening devices, which reach 105110 dB, can cause hearing loss in just five minutes

doi: 10.3390/ijerph19084462

Instead, this large value is a mathematical reflection of the drug's high affinity for tissues relative to its affinity for plasma

Less fluid in the gut means: Less lubrication Firmer stools Slower transit Dehydration also concentrates electrolytes like calcium, which can have constipating effects

I also have dermatographia and also met some with the same condition