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Their weight loss was accompanied by significant reductions in systolic and diastolic blood pressure, triglyceride levels, and glycosylated hemoglobin

The control of tight junction function is key for keeping appropriate gut permeability

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For most people, it lasts a few days to a week and then at least partially subsides as your body adjusts to the medication

Some patients choose to transition to a lower "maintenance" dose once they reach their target weight, while others may eventually taper off as their lifestyle changes become permanent

[41] The major limitation is teratogenicity from topiramate, especially risk of oral clefts with fetal exposure