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doi: 10.1093/alcalc/agn120 20

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Why it matters: Deep sleep is when the brain clears toxins and the body repairs tissue

Clinical choice depends on kinetic goals: SubQ for sustained daily support, IM for faster acute peaks when timing matters

The technique is contraindicated in pregnancy and breastfeeding, in active acne or skin infection, within 6 months of oral isotretinoin, in patients with keloid scarring history, and on anticoagulant therapy without physician clearance

In research models, increased expression of extracellular matrix proteins has been observed, supporting its use in studies of wound healing and skin regeneration