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A new bioRxiv preprint from Kseniia Vlasova and colleagues in Howard Y
Lancet Psychiatry 9:815827 Tate W, Walker M, Sweetman E, Helliwell A, Peppercorn K, Edgar C, Blair A, Chatterjee A (2022) Molecular mechanisms of neuroinflammation in ME/CFS and long covid to sustain disease and promote relapses
Sparsentan (FILSPARI) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively
Although an association with urinary congenital malformations was identified, it was based on limited unadjusted data and may reflect confounding by maternal diabetes or obesity rather than a true treatment effect
The monomeric protein is 236 amino acids in size and is mainly found in the cytosol of liver, pancreas, and kidney cells
In the UK, NICE guidance specifies that these medications should only be prescribed within specialist weight management services and for people meeting specific BMI thresholds (typically BMI 35 kg/m with weight-related comorbidities or 40 kg/m without), alongside diet and physical activity interventions
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