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GLP-1 mediations like semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro, Zepbound) are FDA-approved prescription medications that have shown powerful results for people with obesity and type 2 diabetes

demonstrated that weekly administration of either GLP-1 RA semaglutide or dulaglutide produces a rapid, substantial and dose-dependent reduction in EAT thickness [37], that may bring to a reduction in the pro-inflammatory stimuli

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In orforglipron's study, up to 10% of patients stopped treatment, compared with 3% on placebo

Diabetes Metab Res Rev