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Glycemic effects remain relevant, particularly in patients with prediabetes or insulin resistance, but they are no longer the defining measure of success

If you start both therapies simultaneously and develop nausea, headaches, or fatigue, you cannot determine which medication is responsible

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For example, people who are experiencing loss of kidney function due to diabetes may find that high strength B12 supplementation can cause the loss of function to speed up (House et al., 2010), and high dose supplements of B12 may also increase the risk of colon cancer in older people