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Primary Endpoint Disease-free survival (DFS) Secondary Endpoints: Loco-regional failure-free survival (LRFS), distant metastasis-free survival (DMFS), overall survival (OS), pathological complete response (pCR), R0 resection rate, toxicity, and post-surgical complications Background Locally advanced rectal cancer (LARC) with threatened or involved circumferential resection margins (CRM) represents a high-risk group for recurrence and poor outcomes

H&E staining of organoids was obtained with a Leica DM4B microscope and DMC5400 camera and Leica LAS X software

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Maximizing Results: Lifestyle Factors That Enhance Glucagon Effects While Retatrutide provides pharmacological support for weight loss, lifestyle factors can amplify or diminish its effects