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Depending on cellular state and stress cues, TP53 can promote ferroptosis by repressing SLC7A11 to limit cystine uptake and GSH synthesis, inducing spermidine/spermine N1-acetyltransferase 1 ( SAT1 ) to enhance ROS generation through polyamine catabolism, and upregulating glutaminase 2 ( GLS2 ) to increase -ketoglutarate production and mitochondrial ROS 154-156

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The needle is then secured in place with a piece of tape or bandage, and the IV drip is started

Regular consumption can promote a balanced internal environment and improve cellular function

10.1016/j.kint.2023.06.022 134 Ortega-DomnguezB.Aparicio-TrejoO