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Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance

(Deepalakshmi and Mirunalini, 2011)

However, remaining fat cells may enlarge if the patient gains weight

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Although their beneficial effects, the prolonged releasing of glucocorticoids may result in multiple metabolic and psychological problems [104]

Rotate injection sites to avoid local irritation