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Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes

Cartilage damage and osteoarthritis Acute cartilage injury: Traumatic injuries (sports injuries, accidents) damaging previously healthy cartilage

Methods and Results: In this study, we determined the lowest concentration of doxycycline required for efficient induction of the gene of interest under the control of the Tet-operator and analyzed its impact on the proliferation and viability of two human tumor cell lines HCT116 and A549, which are widely used in scientific research

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2006;136:319S23S