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Disruptions in circadian rhythms can adversely affect sleep quality and lead to imbalances in gut microbiota, resulting in alterations to the community structure, ecological parameters of the microbial ecosystem, and the inflammatory state of the body [45, 214,215,216,217,218,219,220,221]

The purified materials from either the PV1-wtVP 031 - or the PV1-sVP 031 -transformed yeast were analyzed by SDS-PAGE and western blotting with a set of three capsid subunit protein-specific antibodies (Fig.1b)

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