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We systematically analyzed the effects of L1-ATP8B1 on mitochondrial membrane components, key protein expression, and the underlying molecular mechanisms governing its regulation of protein expression

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Building on this mechanistic insight, the team developed a novel combinatorial therapeutic approach pairing lenvatinib with Veratramine (a c-Jun inhibitor), formulated as PKUF-01

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First isolated from human plasma in the early 1970s, it naturally occurs in blood, saliva, and urine but its concentrations decline sharply with age