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2,5 These limitations underscore the urgent need for newer approaches to broaden MDD/TRD treatment options

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Retatrutide is being developed as a once-weekly subcutaneous injection

Mechanistic studies indicate that GLP-1RAs suppress the perception of all basic taste modalities, probably through combined actions in the brainstem and vagal modulation, although paradoxical cases of sweet hypersensitivity have been documented in specific populations (162)

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Studies have shown the health benefits to include a decrease in the risk of stroke and heart attack