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FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability

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In addition, the oxidants may also originate from cytosolic enzyme systems, e.g., NADPH oxidases, and from exogenous triggers such as ionizing radiation and chemotherapeutics

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When cysteine residues in KEAP1 undergo redox oxidation, NRF2 interacts with the Cul3/RING-box protein complex, ultimately leading to NRF2 ubiquitination and subsequent degradation via proteasomes