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However, extreme exhaustion persisting beyond week 8, combined with muscle weakness, severe headaches, or shortness of breath, warrants immediate medical attention

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Patients report significant appetite reduction, meaningful weight loss over time, and gastrointestinal side effects that are consistent in type and severity with brand-name product labeling

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(2023) found that GLP-1 receptor agonists reduced the risk of lower limb amputation by 43% compared to sulfonylureas (HR: 0.57, 95% CI: 0.390.84), with the greatest risk reduction observed in long-term users (HR: 0.44, 95% CI: 0.270.72).(26) However, GLP-1 receptor agonists did not significantly impact diabetic foot ulcer incidence (HR: 1.08, 95% CI: 0.871.35)

Flach, J