Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011
In regard to TC, it is also pertinent to remind the involvement of chemokines (8998) and the peroxisome proliferator-activated receptors (PPARs) in the molecular oncogenesis (95106), so that both types of molecules may serve as novel targets of TC precision therapy or prevention
Nanoscale Research Letters, 8(1), 102.
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