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Through these interactions, GLP-1 stimulates insulin secretion in hyperglycemic states, suppresses glucagon release, slows gastric emptying to regulate nutrient absorption, and acts on the brain to reduce appetite and food intake

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The consensus is that the slowing of gastric emptying, a key therapeutic action of Semaglutide, could inadvertently trigger the hiccup reflex through stomach distension or irritation of the diaphragm or vagus nerve