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PNMT is a cytosolic enzyme that is present in many tissues throughout the body, with particularly high concentration in the adrenal medulla, adrenergic neurons in the amygdala and retina and the left atrium of the heart (Haavik et al., 2008)

Nat Commun 8 (1), 1177 (2017)

A topical agent is applied to the treatment area prior to beginning the skin tightening procedure

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Seniors with eGFR above 30 mL/min/1.73m are typically considered candidates, though individualized evaluation is essential

The only valid in-use shelf life is that stated on the IMP label or trial protocol