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Cellular senescence is characterized by a stable arrest in the cell cycle and encompasses a range of cellular changes that culminate in the development of a complex, pro-inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP), which plays a critical role in fibrosis and tumors by affecting numerous processes, including invasion and therapy resistance 10

Lancet 286(7409):415416

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The delayed gastric emptying, whilst therapeutically beneficial for glucose control and weight management, is also responsible for many of the gastrointestinal side effects associated with these medications