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This designation provides regulatory and commercial incentives to support development for small patient populations

Permanent Deferral : This occurs when a donor is permanently prohibited from donating due to specific health conditions, medications, or medical history

For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells ( In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance (Luis Garcia-Gimenez et al., 2013)

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Prevalence of depression and anxiety in rheumatoid arthritis patients and their associations with serum vitamin D level

Neuroinflammation 22 , 76 (2025)