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This is not surprising given that MRS has been historically used to study (a) high-concentration and easily detectable metabolites at lower field strengths, such as N-acetylaspartate, choline, creatine and myo-inositol (Cleeland et al., 2019, Huibregtse et al., 2021), and (b) low-concentration non-GSH metabolites such as gamma-aminobutyric acid and glutamate (Runia et al., 2022)

One possible alternative pathway to convert GSSG back to GSH is through class III peroxidases

Negative Feedback Loop During this process, as glutathione is produced, there is a negative feedback loop

Koeth, R

Curr Opin Biotechnol 40:185192

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