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15 The plasma concentration of GSH is low because of its rapid turnover, and more than 80% of plasma GSH is removed by the kidney

This study was supported by the Special Coordination Funds for Promoting Science and Technology, Creation of Innovation Centers for Advanced Interdisciplinary Research Areas (Innovative Bioproduction Kobe), MEXT, Japan

A concise table presenting the discussed studies are presented in Table 1

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Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth