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Detection of the resulting COL1A1-PDGFB transcript can provide confirmation of the diagnosis

No indication of an increased risk of thyroid cancer in either selenium deficiency or exogenous supplementation has been reported (182) ( Table 1 )

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182 Additionally, combined inactivation of RNF5 and RNF185 leads to the stabilization of F508del CFTR, suggesting that RNF5 and RNF185 cooperate in the regulation of select substrates, as exemplified by F508del CFTR

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Abildgaard J, Ploug T, Pedersen AT, Eiken P, Pedersen BK, Holst JJ, et al