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doi: 10.1172/JCI990

What makes Tesamorelin unique is its ability to specifically target visceral adipose tissue (VAT) the deep, stubborn belly fat that surrounds internal organs and increases health risks

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Conditional GPX4 knockout mice exemplify the risks of single-pathway targeting: while GPX4 deletion in PT cells protects against early AKI by eliminating damaged cells, long-term deletion activates the cGASSTING pathwaylikely via release of fragmented mitochondrial DNAleading to sustained type I interferon signaling and progressive interstitial fibrosis

Human Psychopharmacology: Clinical and Experimental