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Management of antiplatelets in an acute setting Key Concept: Platelets should be administered in the setting of severe LGIB to maintain a platelet count of .30 3 109 /L, and a higher threshold of .50 3 109 /L can be considered if endoscopic procedures are required

The other works with the neuroendocrine architecture that governs energy balance

This triple mechanism creates a combined metabolic effect that is broader than current single or dual pathway weight loss medications

Ethics declarations Competing interests E.A.S

Klimesova, K., Whittamore, J

Metabolic Reprogramming of Astrocytes in Pathological Conditions: Implications for Neurodegenerative Diseases. International Journal of Molecular Sciences 25: 8922