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In addition to COX-2, mPGES-1 is a rate-limiting enzyme downstream of COX enzymes and specifically converts prostaglandin H 2 to PGE 2

Both acute and subacute toxicity tests demonstrated that M

Nature 360:467471 Kimberlin DW (2004) Neonatal herpes simplex infection

In addition to rosmarinic acid, it inhibits retinal neovascularization through triggering cell cycle arrest in the M and G2 phases [295]

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