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Hadjadj, J

Adverse changes in branched-chain amino acids correlated strongly with hypothyroidism and the associated weight gain

They also rise significantly during calorie restriction, which is one of the core reasons dieting becomes harder over time: the longer you restrict your intake, the more your body pushes back with elevated hunger signals

Keep it refrigerated, check the temperature of your fridge periodically, and respect the beyond-use date

Lichtman et al., N Engl J Med 1992

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