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A deficiency can, therefore, lead not only to the central nervous system manifestations seen in Wernicke encephalopathy but also to peripheral sensorimotor neuropathy, characterized by weakness, numbness, and pain in the extremities

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Together, they help reinforce behavior change and create a more supportive biological environment for sustained weight loss

As predicted by preclinical studies with EPO (5) and ARA 290 (10,38), subjects receiving ARA 290 exhibited significant improvement in glucose control as shown by changes in Hb A 1c concentration