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Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)

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In addition, the requirement for ser/gly pathway metabolites in response to RT was further validated using the isogenic model A549 with NKX2-1 overexpression

Redox homeostasis and cellular stress response in aging and neurodegeneration