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While some lean mass loss inevitably occurs during significant weight reduction, the rate is typically 20-25% of total weight lost on tirzepatide compared to 30-40% with diet-only approaches

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In some histological and electrophysiological experiments, AgRP-IRES-Cre or LepR-IRES-Cre mice were also crossed with the Cre-inducible tdTomato-reporter mouse (B6;129S6-Gt(ROSA)26Sor tm9(CAG-tdTomato)Hze /J, The Jackson Laboratory), allowing the visualization of AgRP or LepR neurons via expression of the tdTomato fluorescent protein

In addition to regulating the menstrual cycle and thickening the uterine lining to support fertility, estradiol binds to estrogen receptors around the body, playing a part in countless body functions as a result

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