Symptoms of inadequate thyroid replacement include fatigue, cold intolerance, weight plateau, and hair loss
The dosing schedule of retatrutide is as follows: Weeks 1-4: 1 mg or 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 8 mg once weekly Week 13+: 8 mg or 12 mg once weekly (Maintenance Dose) However, some trial arms tested higher doses (up to 8 mg or 12 mg as the final dose)
The two companies have been trading blows over the relative merits of their two therapies, with Lilly emphasising that Foundayo can be taken any time of day, without food or water restrictions, while Wegovy has to be taken first thing in the morning on an empty stomach, half an hour before eating or drinking
10.1016/S0006-2952(97)00401-2 Biochem
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